Introduction, Methods, and Executive summary published in JAMA: Network Open May 10, 2022
Full Guideline - Table of Contents:
Question 1: How should the diagnosis of osteomyelitis be established?
Question 2: What is the appropriate management for osteomyelitis underlying a pressure ulcer?
Question 3: When should empiric therapy be administered in the treatment of osteomyelitis?
Question 4: Are there preferred antibiotics with which to treat osteomyelitis?
Question 5: Is oral therapy appropriate for the treatment of osteomyelitis, and if so, what are reasonable patient selection criteria for administration?
Question 6: What is the role and optimal utilization of serial biomarkers and/or imaging studies for assessing treatment response in osteomyelitis?
Question 7: What is the appropriate duration of therapy for typical cases of osteomyelitis?
Brad Spellberg, MD,1 Gloria Aggrey, MD2 Meghan B. Brennan, MD3 Brent Footer, PharmD4 Graeme Forrest, MD5 Fergus Hamilton, MRCP6 Emi Minejima, PharmD1,7 Jessica Moore, PharmD, MS, BCPS8 Jaimo Ahn, MD PhD9 Michael Angarone,10 DO Robert M. Centor,11 MD Kartikeya Cherabuddi, MD12 Jennifer Curran, PharmD13Kusha Davar,1 Joshua Davis, MD14 Mei Qin Dong, Pharm D, BCIDP15 Bassam Ghanem, Pharm.D, MS, BCPS16 Doug Hutcheon, MD1 Philipp Jent, MD17 Minji Kang, MD,18 Rachael Lee, MD MSPH,19 Emily G. McDonald, MD, MSc,20 Andrew M. Morris, MD SM,21 Rebecca Reece MD,22 Ilan S. Schwartz, MD PhD,23 Miranda So, PharmD,24 Steven Tong, MD,25 Christopher Tucker, MD,26 Noah Wald-Dickler,1 Erica J. Weinstein, MD27 Riley Williams II, PharmD, BCIDP,28 Christina Yen, MD18 Shiwei Zhou, MD13 Todd C. Lee MD MPH20 on behalf of the WikiGuidelines Membership
1 Los Angeles County + University of Southern California (USC) Medical Center, Los Angeles, CA, USA
2 Montgomery Medical Associates PC, Rockville, MD, USA
3 University of Wisconsin Hospital and Clinics, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA
4 Providence Portland Medical Center, Portland, OR, USA
5 Rush University Medical Center, Chicago, IL, USA
6 North Bristol NHS Trust, Bristol, UK
7 Department of Clinical Pharmacy, USC School of Pharmacy, Los Angeles, CA, USA
8 Providence Little Company of Mary Medical Center, San Pedro, CA, USA
9 Department of Orthopaedic Surgery, Michigan Medicine, University of Michigan, USA
10 Northwestern University Medical Center, Chicago, IL, USA
11 Department of Medicine, Birmingham Veterans Affairs (VA) Medical Center, Birmingham, AL, USA
12 Department of Medicine, University of Florida, Gainesville, FL, USA
13 Department of Internal Medicine, Division of Infectious Diseases, Michigan Medicine, Ann Arbor, MI, USA
14 Menzies School of Health Research and Charles Darwin University, Darwin, Australia
15 New York Health and Hospitals Bellevue Hospital, NYC, NY, USA
16 King Abdulaziz Medical City, Jeddah, KSA
17 Department of Infectious Diseases, Inselspital Bern University Hospital, Bern, Switzerland
18 UT Southwestern, Dallas, TX, USA
19 Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, USA
20 Clinical Practice Assessment Unit, Department of Medicine, McGill University, Montreal, Canada
21 Department of Medicine, Division of Infectious Diseases, Sinai Health, University Health Network, and University of Toronto, Toronto, Canada
22 Department of Medicine, Section of Infectious Diseases, West Virginia University School of Medicine, USA
23 Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Canada
24 Sinai Health System-University Health Network Antimicrobial Stewardship Program, UHN and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
25 Victorian Infectious Diseases Service, The Royal Melbourne Hospital and University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
26 Hospital Medicine, Magnolia Regional Health Center, Corinth, MS, USA
27 Division of Infectious Diseases, Department of Medicine and Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
28 Pharmacy Service, Oklahoma City VA Health Care System, Oklahoma City, OK, USA
*Corresponding author: Brad Spellberg, MD, 2051 Marengo Street, Los Angeles, CA 90033, [email protected]
Financial Support: None
Financial Disclosures: Author Michael Angarone reports consulting fees from Abbvie. Emily G. McDonald and Todd C. Lee receive research salary support from the Fonds de recherche du Québec – Santé. No other authors have disclosures.